Klf4 atherosclerosis

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August undefined, 2024

WebOn the basis of in vivo KLF4 chromatin immunoprecipitation-sequencing (ChIP-seq) analyses and studies of cholesterol-treated cultured SMCs, we identified >800 KLF4 target genes, including many that regulate pro-inflammatory responses of SMCs. WebAtherosclerosis, the leading cause of death, is a vascular disease of...

KLF4 Signaling Pathway - Creative Diagnostics

WebApr 7, 2024 · Background Although inflammatory cell adhesion molecules (CAMs) and anti-inflammation factor Kruppel-like transcription factor (KLF) 4 have all been reported to be induced after cerebral ischemic stroke (CIS), the close temporal and spatial relationship … WebAtherosclerosis, the leading cause of death, is a vascular disease of... other terms for dancing

Frontiers Role of Vascular Smooth Muscle Cell Plasticity and ...

WebJun 11, 2024 · In addition, a pivotal contribution of KLF4-dependent regulation of macrophage function to cardiovascular disease is exemplified by the observation that myeloid Klf4 deficiency augments vascular inflammation and atherosclerotic lesion formation in Apoe −/− mice . A surprising function of KLF4 in atherosclerosis was also … WebJul 1, 2024 · Nicotine injection with balloon overdilation induces atherosclerotic lesions by activating KLF4 expression. Atherosclerosis is a chronic inflammatory disease characterized by the narrowing of the ... WebFeb 8, 2024 · KLF4 promotes phenotypic modulation into macrophage-like and Sca1-expressing mesenchymal-like VSMCs, while MSCs differentiate into VSMCs in vitro when exposed to TGFβ and PDGF-BB. VSMCs might also derive from ECs following EndMT driven by TGFβ signalling. rockingham skin and medical centre

Vascular smooth muscle cells in atherosclerosis: time for a re ...

Stem Cell Pluripotency Genes Klf4 and Oct4 Regulate

WebNov 26, 2024 · In this mechanism induced by oxidized low-density lipoprotein (oxLDL), the KLF4 factor suppresses the expression of VSMC genes (SM22α, ACTA2, MYH11) by binding to the G/C repressor element in the gene promoter and by inhibiting the binding of transcription factors to the CArG element mechanism, leading to phenotypic switching ( … rockingham skin cancer clinic bulk billingWebJan 1, 2008 · Herein we hypothesize that KLF4 is an important regulator in different phase of atherosclerosis and may be a novel target of prevention and cure of atherosclerosis. Further investigation is needed to approach the concrete signaling pathways about KLF4. rockingham simpson

"WebMar 1, 2024 · Atherosclerosis is an important problem in modern medicine, the keys to understanding many aspects of which are still not available to clinicians. ... The large family of KLFs in humans includes 18 members, among which KLF2 and KLF4 are at the crossroads between endothelial cell mechanobiology and immunometabolism, which play … " - Klf4 atherosclerosis

Klf4 atherosclerosis

Krüppel-Like Factors : Crippling and Uncrippling ... - ScienceDirect

WebMar 29, 2024 · CSC increased the expression of inflammatory markers and reduced the contractile ones in both cell types, with KLF4 modulating the SMC phenotypic switch. Next, we performed a mass spectrometry-based differential proteomic approach on human SMCs and could show 11 proteins were significantly affected by exposition to CSC (FC ≥ 2.7, p ≤ … WebJul 17, 2024 · Taken together, our results suggest that most SMC phenotypes in advanced atherosclerotic lesions are conserved between humans and mice, and, taken with previous knowledge that SMC Klf4 is atheropromoting in mice and contains a human GWAS CAD …

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WebOct 11, 2012 · In summary, our observations implicate myeloid KLF4 as a key regulator of experimental atherogenesis in mice. The fact that KLF4 has been shown to confer favorable anti-inflammatory effects in both the … WebOct 3, 2024 · Conclusions: KLF4 transactivates Ch25h and LXR, thereby promoting the synergistic effects between ECs and macrophages to protect against atherosclerosis susceptibility. Keywords: atherosclerosis; cholesterol; endothelial cells; inflammation; …

WebFeb 1, 2024 · Concordantly, cardiac-specific Klf4–/– mice develop heart dysfunction with aging or pressure overload associated with reduced ATP production, increased reactive oxygen species production, and mitochondrial dysfunction. WebAtherosclerosis, the leading cause of death, is a vascular disease of...

WebJan 1, 2024 · These results indicate that formononetin may regulate KLF4 expression during atherosclerosis development. Given the role of KLF4 and SRA in atherogenesis, we postulate that formononetin may be antiatherogenic, in part, through regulation of KLF4-SRA … WebApr 8, 2024 · The anti-inflammation and antifibrosis may be one of the mechanisms of KLF4 against atherosclerosis . However, KLF4 activated NF-κB signaling pathway and affected the release of pro-inflammatory ...

WebJan 1, 2024 · As a zinc finger domain-containing transcription factor, KLF4 involves in atherosclerosis development 27, 65. More importantly, it is reported that KLF4 is a critical regulator of macrophage polarization, and expression of KLF4 was robustly induced in M2 macrophages while markedly reduced in M1 macrophages 31.

WebDec 1, 2014 · Blockade of mir-92a restores Klf2 and Klf4 expression, reduces endothelial inflammation and monocyte infiltration, thereby limiting atherosclerosis. 19 Disturbed flow and other proatherogenic factors also downregulate the endothelial expression of negative guidance cues, particularly Netrin-1 and Semaphorin3A, while upregulating EphrinB2, and … other terms for dadWebMay 18, 2015 · On the basis of in vivo KLF4 chromatin immunoprecipitation–sequencing (ChIP-seq) analyses and studies of cholesterol-treated cultured SMCs, we identified >800 KLF4 target genes, including many... other terms for data vaultWebKLF4 plays an important role in several vascular diseases where it was shown to regulate vascular inflammation by controlling macrophage polarization and plaque formation in atherosclerosis. It up-regulates Apolipoprotein E, which is an anti-atherosclerotic factor. It is also involved in the regulation of angiogenesis. other terms for deathWebDec 13, 2024 · KLF4 is a zinc-finger-containing transcription factor that plays a crucial role in maintaining cell senescence in response to cellular stress. Studies have shown that KLF4 typically upregulates p21 to promote cell growth arrest ( Chew et al., 2011 ). other terms for cybersecurityWebFeb 13, 2024 · KLF4-dependent phenotypic modulation of smooth muscle cells has a key role in atherosclerotic plaque pathogenesis. Nat Med. 2015; 21:628–637. doi: 10.1038/nm.3866 Crossref Medline Google Scholar; 13. Cherepanova OA, Gomez D, Shankman LS, Swiatlowska P, Williams J, Sarmento OF, Alencar GF, Hess DL, Bevard MH, … rockingham small businessesWebAug 1, 2024 · However, since the clinical consequences of atherosclerosis typically occur well after our reproductive years, we sought to identify beneficial KLF4-dependent SMC functions that were likely to be evolutionarily conserved. We tested the hypothesis that … other terms for debriefWebDec 5, 2024 · Our study indicates that KLF4 mediates the link between glycolytic switch and VSMCs phenotypic transitions, suggesting that a previously unrecognized KLF4-eEF1A2/circCTDP1-PFKFB3 axis plays... rockingham slot car club