Diethylene glycol metabolism

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August undefined, 2024

WebOften colored fluorescent yellow-green when used in automotive antifreeze. DESCRIPTION: Ethylene glycol is a useful industrial compound found in many consumer products. Examples include antifreeze, hydraulic brake fluids, some stamp pad inks, ballpoint pens, solvents, paints, plastics, films, and cosmetics. It can also be a pharmaceutical vehicle. WebDec 21, 2012 · Diethylene glycol (DEG) is a clear, colorless, odorless liquid with a sweet taste, and is an excellent solvent for water-insoluble chemicals and drugs. DEG is used …

Ethylene Glycol and Other Glycols SpringerLink

WebNov 28, 2024 · Like ethyl alcohol and methanol, ethylene glycol is metabolized by ADH. In this step it forms glycoaldehyde. Through interaction with aldehyde dehydrogenase, … WebDiethylene glycol is rapidly absorbed and distributed to the kidneys, brain, liver, spleen, and adipose tissue. The kidneys receive most of the DEG. The volume of distribution of … retirement communities in henderson county nc

Diethylene Glycol - an overview ScienceDirect Topics

WebJun 14, 2015 · This glycolic acid cannot be metabolised in an acid-scavenging way, like lactate or ketones. Thus, this acidosis is "bicarbonate-resistant". More bicarbonate must be added in order to buffer the excessive number of hydrogen ions present in the patient, so that H 2 O and CO 2 may be generated. WebNov 28, 2024 · From 12 to 48 hours, ethylene glycol metabolites produce severe anion gap metabolic acidosis with compensatory hyperventilation. The acidosis results primarily from an increase in glycolic acid, although glyoxylic, oxalic, and lactic acids also contribute in small part. Calcium oxalate crystals are deposited in the brain, lungs, kidneys, and heart. WebFeb 1, 1989 · Metabolism of diethylene glycol (1.1 g/kg) by male Wistar rats Group Route of DEG administration Pretreatment Urine Percent DEG radioactivity* Percent HEAA I II III IV Intragastric Intravenous Intragastric Intragastric None None Pyrazole Diethyldithiocarbamate 79.5 ± 0.6 80.3 ± 2.8 98.1 ± 1.5 93.1 ±0.6 20.5 ± 0.6 19.7 ±2.8 … retirement communities in highlands ranch co

Ethylene glycol poisoning: a rare but life-threatening cause of ...

National Center for Biotechnology Information

WebThe most common cause of tachypnea is uncompensated metabolic acidosis. Ethylene glycol poisoning through ingestion can cause noncardiogenic pulmonary edema and ARDS. Ethylene glycol poisoning can cause dysrhythmias and heart failure. Ethylene glycol toxicity is characterized by an osmolal gap and metabolic acidosis with an elevated … retirement communities in hot springs arkWebJul 29, 2011 · The ethylene glycol (EG) metabolites glycolic acid (GA) and oxalic acid (OA) were not detected in any of these studies. In DEG-intoxicated patients, oxalate crystals have also not been found in the urine or kidney tissues ( Alfred et al., 2005; Brophy et al., 2000; Okuonghae et al., 1992 ). retirement communities in huntington wv

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Diethylene glycol metabolism

Inhibition of Metabolism of Diethylene Glycol Prevents Target …

WebJun 14, 2015 · Ethylene glycol is a traditional cause of high anion gap metabolic acidosis, and occupies the "E" spot in the MUDPILES mnemonic. The chief cause of metabolic … WebJul 1, 2024 · Diethylene glycol is an organic liquid compound with the chemical structure: CH 2 OHCH 2 OCH 2 CH 2 OH. It is a colorless, odorless, hygroscopic liquid with a …

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WebApr 1, 2012 · Measurement of the serum levels of ethylene glycol or the degradation products is helpful, but not in case of emergency because analysis takes several days. Mostly, the patients present with a metabolic acidosis (86% at time of presentation) with an elevated anion gap or widened osmolal gap on admission . The differential diagnosis of a ... WebDiethylene glycol (DEG) is a sweet-tasting, colorless, nonodoriferous, hygroscopic liquid commonly used in the commercial preparation of antifreeze, brake fluid, cigarettes, and …

WebNov 1, 2007 · Diethylene and ethylene glycols are both metabolized by alcohol and aldehyde dehydrogenases to produce toxic metabolites. Both glycols produce coma, … WebAug 14, 2014 · Metabolism. Diethylene glycol monoethyl ether is metabolized by cytochrome P450 enzymes and in particular by alcohol dehydrogenase. In an adult volunteer given a single oral dose of 11.2 mmol diethylene glycol monoethyl ether, 68% of the dose was eliminated with the urine as 2-(2-ethoxyethoxy)acetic acid. ...

WebEthylene glycol is metabolized in the liver to a variety of more toxic compounds. In untreated adults, approximately 20% of a dose of ethylene glycol is excreted unchanged by the kidneys. The half-life of ethylene … WebJun 7, 2010 · Diethylene glycol (DEG) is an industrial chemical, the misuse of which has led to numerous epidemic poisonings worldwide. The mechanism of its toxicity has not been defined as to the precise relationship between the …

WebFeb 27, 2024 · Diethylene glycol was once used as a vehicle for the drug sulphanilamide and when used for this it caused some 76 deaths. ... The mechanism of toxicity of ethylene glycol involves metabolism, but …

WebThese results indicate that DGA produces mitochondrial dysfunction by chelating calcium to decrease the availability of substrates and of reducing equivalents to access Complex I and by inhibiting Complex II activity at higher concentrations. retirement communities in howell miWebcoingestants (eg, ethanol inhibits diethylene glycol metabolism). Oliguric or anuric acute kidney failure with metabolic acidosis is typical. Death can occur 2 to 7 days after the onset of anuria in untreated patients; the other patients usually remain dialysis dependent. Renal ultrasound shows enlarged or swollen kidneys retirement communities in idaho stateWebThe metabolite was isolated and characterized by 13C-NMR to be 2- (hydroxy) ethoxyacetic acid (HEAA). Confirmation of identity was provided by synthesis of HEAA and comparison of its NMR spectra and chromatographic behavior with those of the metabolite. retirement communities in houston texas areaWebAug 18, 2011 · Diethylene glycol (DEG; 2,2′-oxybisethanol; CAS RN 111-46-6) is an industrial solvent that may present a significant health challenge because of its presence in commercial products, which can be mistakenly or intentionally ingested (Marraffa et al., 2008).Most modern poisoning cases have involved illegal substitution as a solvent in … ps3 skins coversWebSep 26, 2024 · National Center for Biotechnology Information retirement communities in kitsap county waWebApr 10, 2024 · This week, the Chinese diethylene glycol market fluctuated and went up, and the Chinese diethylene glycol market was affected by the tightening of spot circulation, and the market performance was firm. ... Drug Metabolism. Feed Additive. Anti-stress Drugs. Drugs Influencing Immune Function. Veterinary Raw Materials. retirement communities in kansas cityWebDiethylene glycol (DEG) exposure poses risks to human health because of widespread industrial use and accidental exposures from contaminated products. … retirement communities in newberg or