In vitro-activated chicken ovalbumin (OVA)-specific OT1 CTLs were confronted with transformed mouse embryonic fibroblasts expressing the OVA peptide (MEC-1/OVA) and the co-stimulatory molecule B7.122,23. In contrast to tumor cells that evolved in vivo, this engineered model lacks natural immune … See more To compare effector function against solid tumor cells, which typically retain resistance to CTL-mediated killing, OT1 CTL were confronted with mouse melanoma B16F10 … See more Across all tested tumor models, sequential or simultaneous contacts by multiple CTL with the same target cell occurred before target cell death … See more To address whether transient perforin pores were associated with structural intracellular damage, B16F10/OVA cells were engineered to express green fluorescent … See more We then addressed whether apoptosis could have been induced by rare deadly CTL hits (“stochastic killing”) or, instead, by sublethal contacts that add up over time (“additive … See more WebDec 23, 2004 · Finally, the observation that clearance of hepatic adenovirus-encoded mRNA proceeds in an accelerated manner in B6.lpr → B6 chimeras with Fas-defective CTL but intact hepatocyte Fas receptors likely reflects the effects of the compensatory upregulation of FasL expression that has been observed in Fas-deficient T cells. 39 This finding ...
T cell receptor-induced Fas ligand expression in cytotoxic …
WebJun 1, 2002 · We now know that CTLs can kill through the FAS (CD95; a member of the tumour-necrosis factor receptor family of death receptors) pathway, which requires neither calcium nor perforin 6, 7, 8. It... Web細胞傷害性T細胞（さいぼうしょうがいせいTさいぼう、英: cytotoxic T lymphocyte or cytotoxic T cell; TcまたはCTL）とは、リンパ球T細胞のうちの一種で、宿主にとって異物になる細胞（移植細胞、ウイルス感染細胞、癌細胞など）を認識して破壊する。 キラーT細胞（英: killer T cell ）とも呼ばれる 。 hank williams christmas songs
Fas and TNFR1, but not cytolytic granule‐dependent mechanisms …
Weba) Antigen presented via MHC class I is recognized by CTLs. b) APC presentation occurs to both TC and TH cells. c) Fas-FasL signaling pathway is activated, triggering apoptosis in target cell. d) Histamine is released from cytoplasmic granules, recruiting macrophages to the site of infection. WebCTLLenders funds Credit Tenant Lease Financing (CTL) for real estate property developers and owners on a variety of NNN, NN, or ground leases property types. The principals of … WebFas/APO-1 is a member of the tumor necrosis factor receptor family of proteins that induces apoptosis when cross-linked with monoclonal antibody (mAb) or with its physiological … hankwilliams.com