Cisplatin resistance mechanism

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August undefined, 2024

WebCisplatin resistance. Cisplatin combination chemotherapy is the cornerstone of treatment of many cancers. Initial platinum responsiveness is high, but the majority of cancer … WebTherapeutic efficacy of cisplatin-based treatment of late stage urothelial carcinoma (UC) is limited by chemoresistance. To elucidate underlying mechanisms and to develop new approaches for overcoming resistance, we generated long-term cisplatin treated (LTT) UC cell lines, characterised their cisplatin response, and determined the expression of …

FAM83B inhibits ovarian cancer cisplatin resistance through

WebJan 10, 2014 · Here, we review the molecular mechanisms of cisplatin resistance. These include methods to reduce cisplatin bioavailability within a cell, and defects in the machinery that produces cell death following cisplatin-induced DNA damage. While overcoming these mechanisms is a potential therapeutic approach that can increase … WebFeb 25, 2024 · Autophagic flux in cisplatin-resistant ovarian cancer cells is caused by cisplatin. At present, the cytoprotective function of autophagy in cancer cells is considered a potential chemotherapy resistance mechanism. Most studies have suggested that targeting autophagy-related molecules may increase the chemosensitivity of cancer cells … dallas cowboys football game watch

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WebSep 24, 2024 · Cisplatin exerts anticancer activity via multiple mechanisms. Its most acceptable mechanism involves the formation of DNA–platinum adducts by interacting … WebIt has been established that the mechanism of cisplatin resistance includes reduced drug uptake, increased drug inactivation, increased DNA adduct repair, and inhibition of the … WebOct 13, 2024 · An overview of the categories of platinum resistance mechanisms represented in the database is provided below. Regulation of drug entry, exit, accumulation, sequestration, and detoxification... birch + butcher milwaukee wi

Mechanisms of resistance to cisplatin - ScienceDirect

Cisplatin resistance can be curtailed by blunting Bnip3-mediated ...

WebApr 22, 2024 · Resistance to cisplatin, a platinum-based drug used as first-line chemotherapy treatment is a prominent example that has been extensively studied in … WebSilencing USP14 increased the tumor antagonistic action of DDP in A549 cisplatin-resistant (A549/DDP) cells, while USP14 overexpression decreased the antagonist … birch by helix natural mattressWebMar 3, 2008 · Resistance to platinum chemotherapy is multifactorial ( 2 – 6 ). There are five recognized DNA repair pathways that protect cellular DNA from injury: nucleotide excision repair, mismatch repair (MMR), double-strand break … dallas cowboys football jacket

"WebAug 24, 2024 · Components of tumor microenvironment reported to affect cisplatin resistance. These components can contribute to cisplatin resistance through decreased … " - Cisplatin resistance mechanism

Cisplatin resistance mechanism

Cisplatin resistance and opportunities for precision medicine

WebSep 9, 2014 · Another resistance mechanism to cisplatin and oxaliplatin is increased glutathione concentration, which inactivates platinum compounds before DNA damage occurs. Metallothioneins are small cysteine-rich proteins involved in metal detoxification and may play a role as stress proteins in response to platinum complexes. 76 Once inside … WebApr 13, 2024 · Researchers at the University Hospital Bonn (UKB) have now been able to elucidate a mechanism underlying cisplatin resistance in testicular cancer. Using CRISPR gene scissors, they identified the NAE1 gene as its driver. Inhibiting this resistance mediator by adding the NAE1 inhibitor MLN4924 not only restores the effect of cisplatin, …

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WebOct 5, 2014 · The proposed mechanisms of cisplatin resistance include changes in cellular uptake and efflux of cisplatin, increased biotransformation and detoxification in the liver, and increase in DNA repair and anti-apoptotic mechanisms (Gottesman, Fojo et al., 2002) . To overcome resistance, cisplatin is commonly used in combination with some … WebCisplatin resistance arises through a multifactorial mechanism involving reduced drug uptake, increased drug inactivation, increased DNA damage repair, and inhibition of transmission of DNA damage recognition signals to the apoptotic pathway.

WebSep 5, 2011 · Cisplatin exerts anticancer effects via multiple mechanisms, yet its most prominent (and best understood) mode of action involves the generation of DNA lesions … WebDDP has gradually become the standard chemotherapy method for chronic lung adenocarcinoma and postoperative grade II and III lung adenocarcinoma. 8 Although lung adenocarcinoma reacts well in the initial stage of standard cisplatin chemotherapy, significant DDP resistance develops before chemotherapy (primary resistance) or …

WebThe mechanism of action of cisplatin has been associated with ability to crosslink with the urine bases on the DNA to form DNA adducts, preventing repair of the DNA leading to DNA damage and subsequently induces apoptosis within cancer cells. WebReducing cisplatin accumulation appears to be a major mechanism of acquired resistance. In one study, variants of an ovarian carcinoma line with increasing resistance showed decreasing levels of cisplatin accumulation, which could be measured as early as 5 min following treatment.

WebJun 15, 2024 · Based on the above reasons, this study mainly explored the molecular mechanism of DDP resistance in TNBC. We argue that the miR-133b-fibroblast growth factor receptor 1 (FGFR1) axis may mediate the tumor growth and DDP resistance of TNBC by regulating the Wnt-β-catenin pathway. miR-133b is related to the survival and …

Web2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need … dallas cowboys football hatWebFeb 28, 2024 · Three mechanisms define cisplatin’s direct involvement, demonstrating the chemo-resistant tumor cell phenotype: pre-target, on-target, and post-target resistance [20,21,22]. The first is characterized by reduced intracellular accumulation and increased cisplatin sequestration caused by GSH and other scavengers. dallas cowboys football helmet drawingWebOct 23, 2003 · The mechanisms responsible for cisplatin resistance are several, and contribute to the multifactorial nature of the problem. Resistance mechanisms that limit the extent of DNA damage... dallas cowboys football injuriesWebJan 9, 2024 · Mechanism analysis showed FAM83B interacted with APC to inhibit Wnt pathway activity, causing ovarian cancer cisplatin resistance. We also found FAM83B levels were negative with Wnt pathway ... birch by helix bed frame reviewsWebAug 24, 2024 · New Insights into Mechanisms of Cisplatin Resistance: From Tumor Cell to Microenvironment. Although cisplatin has been a pivotal chemotherapy drug in treating … birch by helix bed reviewsWebUnfortunately, many cancers initially respond to platinum treatment but when the tumor returns, drug resistance frequently occurs. Resistance to cisplatin is attributed to three molecular mechanisms: increased DNA repair, altered cellular accumulation, and increased drug inactivation. birch by helix mattress reviewWebCisplatin DNA damage is repaired through four major mechanisms, including double-strand break repair (DSSR), mismatch repair (MMR), base excision repair (BER), and nucleotide excision repair (NER) ( Figure 2A … dallas cowboys football ornaments