WebCisplatin was the first of the platinum-based chemotherapeutic agents and therefore has been extensively studied as an antitumor agent since the late 1960s. Because this agent … WebCisplatin analysis by HPLC especially in biologic samples is challenging due to formation of different species and its high reactivity. Derivation by specific agents can serve a simpler …
Doseâ Dependent Protection by Lipoic Acid against Cisplatinâ …
WebFeb 28, 2024 · Gold nanoparticles enhance cisplatin delivery and potentiate chemotherapy by decompressing colorectal cancer vessels. Xiaoxu Zhao 1 Department of General Surgery, ... HPLC analysis detected high concentrations of cisplatin in tumors after combined therapy, both of which indicated that the delivery efficacy of cisplatin was … WebCisplatin is an anti-tumor agent widely employed in cancer chemotherapy. A specific and selective method for the quantitative determination of cisplatin in human plasma and its applications to pharmacokinetic … dmv 349 code sheet
Development of HPLC conditions for valid determination of
WebCisplatin was the first of the platinum-based chemotherapeutic agents and therefore has been extensively studied as an antitumor agent since the late 1960s. Because this agent forms several DNA adducts, a highly sensitive and specific quantitative assay is needed to correlate the molecular dose of individual adducts with the effects of treatment. WebHPLC is a useful technique for monitoring 2 and 3, but only if the components of the mobile phase used in the reverse phase HPLC technique are unreactive toward these aqua complexes under the conditions of the experiment. 15N Nuclear magnetic resonance (NMR) with samples highly enriched (>98%) in 15N has been used to check the reactivity of 2 … WebAug 15, 2007 · Paclitaxel and platinum analogs (cisplatin and carboplatin) is one such FDA approved combination administered sequentially for the treatment of different types of cancers; for example carboplatin in combination with paclitaxel is an approved therapy in patients with non small cell lung cancer (NSCLC), advanced and recurrent cervical … cream couch cover